9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID CAS#: 64072-89-5

9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID Basic information

Product Name:

9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID

Synonyms:

DELTA12-PROSTAGLANDIN D2
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID
(5z,9-alpha,12e,15s)-9,15-dihydroxy-11-oxoprosta-5,12-dien-1-oicacid
9,15-dihydroxy-11-oxo-,(5z,9-alpha,12e,15s)-prosta-12-dien-1-oicacid
delta(sup12)-pgd2
delta(sup12)-prostaglandind2
(5Z,12E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,12-dien-1-oic acid
Δ12-PGD2

CAS:

64072-89-5

MF:

C20H32O5

MW:

352.47

Mol File:

64072-89-5.mol

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9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID Chemical Properties

solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml

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9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID Usage And Synthesis

Description

Prostaglandin D₂ (PGD₂) is one of the five primary enzymatic prostaglandins derived directly from PGH₂. PGD₂ is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD₂ is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ¹²-PGD₂ is one of the initial chemical decomposition products of PGD₂. Δ¹²-PGD₂ is an intermediate in the pathway leading to Δ¹²-PGJ₂, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of Δ¹²-PGD₂ involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.

Uses

Δ12(E)-Prostaglandin D2 is a derivative of Prostaglandin D2 (HY-101988). Prostaglandin D2 is one of the major Prostaglandins actively produced in the brain of various mammals[1].

References

[1] J Atsmon, et al. Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2. Biochemistry. 1990 Apr 17;29(15):3760-5. DOI:10.1021/bi00467a023

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