(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P Basic information
- Product Name:
- (D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
- Synonyms:
-
- ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
- (D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
- H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
- substance P, Pro(2)-Phe(7)-Trp(9)-
- (D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P)
- Substance P, (D-Pro2, D-Phe7, D-Trp9)
- Substance P, 2-D-proline-7-D-phenylalanine-9-D-tryptophan-
- CAS:
- 77275-70-8
- MF:
- C72H105N19O13S
- MW:
- 1476.79
- Product Categories:
-
- Antagonist
- Peptides for Cell Biology
- Tachykinins
- Mol File:
- 77275-70-8.mol
(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P Chemical Properties
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Solid
- pka
- 13.27±0.46(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P Usage And Synthesis
Uses
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].
in vivo
[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].
References
[1] Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8. DOI:10.1016/0014-2999(82)90189-3
[2] Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6. DOI:10.1111/j.1748-1716.1981.tb06771.x
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