1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Basic information
- Product Name:
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Synonyms:
-
- COMPOUND 4
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Compound IIII
- Kv1.5IN4
- Kv1.5INIIII
- Kv1.5-IN-IIII
- Kv1.5INIV
- Kv-1.5-IN-IIII,Kv1.5 IN IIII
- CAS:
- 1469902-72-4
- MF:
- C19H18ClNO3
- MW:
- 343.8
- Product Categories:
-
- MRP
- Multi-Drug Resistance
- Drug Efflux Pumps
- L to
- Modulators for MRP TransportersEnzyme Inhibitors by Enzyme
- Mol File:
- Mol File
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Chemical Properties
- solubility
- DMSO: 10 mg/mL, soluble
MSDS
- Language:English Provider:SigmaAldrich
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Usage And Synthesis
Uses
Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.
References
[1] Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors