Basic information Safety Supplier Related

5-METHOXY-2-METHYLINDOLE

Basic information Safety Supplier Related

5-METHOXY-2-METHYLINDOLE Basic information

Product Name:
5-METHOXY-2-METHYLINDOLE
Synonyms:
  • 5-Methoxy-2-methylindole, 99+%
  • 5-METHOXY-2-METHYLINDOLE
  • AKOS JY2082626
  • 5-Methoxy-2-methyindole
  • Indole, 5-methoxy-2-methyl-
  • 5-Methoxy-2-Methylindole, 99+% 25GR
  • 5-Methoxy-2-Methylindole, 99+% 5GR
  • 2-Methyl-5-Methoxyindole
CAS:
1076-74-0
MF:
C10H11NO
MW:
161.2
EINECS:
214-066-5
Product Categories:
  • Building Blocks
  • C10
  • Aromatics
  • Heterocycles
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Indole
  • Indoles
  • Simple Indoles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Indoles and derivatives
Mol File:
1076-74-0.mol
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5-METHOXY-2-METHYLINDOLE Chemical Properties

Melting point:
86-88 °C (lit.)
Boiling point:
145 °C / 1.5mmHg
Density 
1.0840 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol (very faint turbidity.)
pka
17.28±0.30(Predicted)
form 
Crystalline Powder or Crystals
color 
White to light beige
InChIKey
VSWGLJOQFUMFOQ-UHFFFAOYSA-N
CAS DataBase Reference
1076-74-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900

MSDS

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5-METHOXY-2-METHYLINDOLE Usage And Synthesis

Description

5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis.

Chemical Properties

white to light beige crystalline powder or

Uses

An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis.

Uses

reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5

References

https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en&region=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure

5-METHOXY-2-METHYLINDOLE Preparation Products And Raw materials

Raw materials

5-METHOXY-2-METHYLINDOLESupplier

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