5-METHOXY-2-METHYLINDOLE Chemical Properties

Melting point:

86-88 °C (lit.)

Boiling point:

145 °C / 1.5mmHg

Density 

1.0840 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in methanol (very faint turbidity.)

form 

Crystalline Powder or Crystals

pka

17.28±0.30(Predicted)

color 

White to light beige

InChIKey

VSWGLJOQFUMFOQ-UHFFFAOYSA-N

CAS DataBase Reference

1076-74-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-METHOXY-2-METHYLINDOLE Usage And Synthesis

Description

5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis.

Chemical Properties

white to light beige crystalline powder or

Uses

An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis.

Uses

reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5

Uses

It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.

Definition

ChEBI: 5-Methoxy-2-methyl-1H-indole is a member of indoles.

References

https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en&region=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure

5-METHOXY-2-METHYLINDOLE(1076-74-0)Related Product Information

• 6-METHOXY-1,2,3,4-TETRAHYDRO-9 H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE
• 6-Methoxyharmalan
• 5-BENZYLOXYINDOLE-2-CARBOXYLIC ACID
• Indometacin
• ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
• ETHYL 5-METHOXYINDOLE-2-CARBOXYLATE
• ETHYL 5,6-DIMETHOXYINDOLE-2-CARBOXYLATE
• 5-METHOXYINDOLE-2-CARBOXYLIC ACID
• 5-METHOXY-2-METHYLINDOLE
• 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
• 5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
• 5,6-DIMETHOXYINDOLE-2-CARBOXYLIC ACID
• 1-[P-CHLOROBENZOYL]-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID CARBOXYMETHYL ESTER
• 5-METHOXY-4-METHYLINDOLE
• 4-methoxy-2-methyl-1H-indole
• 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE,3-Formyl-5-methoxy-1-methylindole
• 4-METHOXY-1-METHYLINDOLE
• 2-Methylindole