3-PHENYL-1-INDANONE Chemical Properties

Melting point:

75-78 °C (lit.)

Boiling point:

148 °C/0.7 mmHg (lit.)

Density 

1.162

refractive index 

1.5361 (estimate)

storage temp. 

Sealed in dry,Room Temperature

InChI

1S/C15H12O/c16-15-10-14(11-6-2-1-3-7-11)12-8-4-5-9-13(12)15/h1-9,14H,10H2

InChIKey

SIUOTMYWHGODQX-UHFFFAOYSA-N

SMILES

O=C1CC(c2ccccc2)c3ccccc13

CAS DataBase Reference

16618-72-7

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

NK7538200

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02960,

MSDS

• Language:English Provider:SigmaAldrich

3-PHENYL-1-INDANONE Usage And Synthesis

Uses

3-Phenyl-1-indanone can be used as a pharmaceutical synthesis intermediate and can be used in laboratory research and development processes.

Synthesis

Under the protection of high-purity nitrogen, 0.05 mmol of heteronuclear ruthenium-palladium bicyclic metal compound 1, 1 mmol of o-iodoacetophenone, 2.5 mmol of benzyl alcohol, 2 mmol of potassium hydroxide, and 3 ml of dioxin were added to a 10 ml Schlek reaction tube, and the reaction tube was displaced with nitrogen for three times, and then the reaction was refluxed for 30 hours by heating with an oil bath under magnetic stirring to 110??C. The reaction was carried out with the addition of 3 ml of water. Remove the oil bath, the water bath was reduced to room temperature; to the reaction solution added 3 ml of water, extracted with 5 ml of dichloromethane three times, the organic phase was combined and dried with anhydrous MgSO4 for 30 minutes, filtration, the filtrate was concentrated with a rotary evaporator, and the residue was used as a spreading agent with a mixture of dichloromethane/petroleum ether, separated by silica gel thin-layer chromatography, to obtain the pure product of 3-phenyl-1-indanone.

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• 2-(3-[4-(DIMETHYLAMINO)PHENYL]-2-PROPENYLIDENE)-7-(4-METHOXYPHENOXY)-3-PHENYL-1-INDANONE
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