RS 23597-190 HYDROCHLORIDE
RS 23597-190 HYDROCHLORIDE Basic information
- Product Name:
- RS 23597-190 HYDROCHLORIDE
- Synonyms:
-
- 3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
- 3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride
- 4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
- 3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL
- 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE
- RS 23597-190 HYDROCHLORIDE
- RS23597-190HCl
- 4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride
- CAS:
- 149719-06-2
- MF:
- C16H24Cl2N2O3
- MW:
- 363.28
- Mol File:
- 149719-06-2.mol
RS 23597-190 HYDROCHLORIDE Chemical Properties
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 100 mM in water
RS 23597-190 HYDROCHLORIDE Usage And Synthesis
Uses
RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.
Biological Activity
A high affinity, selective competitive antagonist at 5-HT 4 receptors.
Biochem/physiol Actions
RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).
storage
Store at RT
RS 23597-190 HYDROCHLORIDESupplier
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RS 23597-190 HYDROCHLORIDE(149719-06-2)Related Product Information
- METHYL 5-CHLORO-2-METHOXYBENZOATE
- Methyl 4-amino-2-methoxybenzoate
- 5-Chloro-2-methoxybenzoic acid
- Methyl 5-chloro-2-hydroxybenzoate
- 5-Amino-4-chloro-2-methylphenol
- 4-AMINO-5-CHLORO-2-ETHOXYBENZOIC ACID
- 2-Ethoxy-4-amino-5-chlorobenzoic acid
- METHYL 4-AMINOSALICYLATE
- 2-Chloro-5-methoxyaniline
- METHYL 4-AMINO-3-CHLOROBENZOATE
- 5-Chloro-2-hydroxybenzoic acid
- 4-AMINO-2-METHOXYBENZOIC ACID
- 4-AMINO-3-CHLORO-BENZOIC ACID ETHYL ESTER
- RS 23597-190 HYDROCHLORIDE
- 4-Amino-3-chlorobenzoic acid