RS 23597-190 HYDROCHLORIDE Chemical Properties

storage temp. 

Sealed in dry,2-8°C

solubility 

Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)

form 

Powder

Water Solubility 

Soluble to 100 mM in water

RS 23597-190 HYDROCHLORIDE Usage And Synthesis

Uses

RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.

Biological Activity

A high affinity, selective competitive antagonist at 5-HT 4 receptors.

Biochem/physiol Actions

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).

storage

Store at RT

RS 23597-190 HYDROCHLORIDE(149719-06-2)Related Product Information

• METHYL 5-CHLORO-2-METHOXYBENZOATE
• Methyl 4-amino-2-methoxybenzoate
• 5-Chloro-2-methoxybenzoic acid
• Methyl 5-chloro-2-hydroxybenzoate
• 5-Amino-4-chloro-2-methylphenol
• 4-AMINO-5-CHLORO-2-ETHOXYBENZOIC ACID
• 2-Ethoxy-4-amino-5-chlorobenzoic acid
• METHYL 4-AMINOSALICYLATE
• 2-Chloro-5-methoxyaniline
• METHYL 4-AMINO-3-CHLOROBENZOATE
• 5-Chloro-2-hydroxybenzoic acid
• 4-AMINO-2-METHOXYBENZOIC ACID
• 4-AMINO-3-CHLORO-BENZOIC ACID ETHYL ESTER
• RS 23597-190 HYDROCHLORIDE
• 4-Amino-3-chlorobenzoic acid