GW 9578 Chemical Properties

Boiling point:

641.7±55.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);5.07(Max Conc. mM)

pka

3.77±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

GW 9578 Usage And Synthesis

Uses

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].

IC 50

mouse PPARα: 5 nM (EC₅₀); h-PPARα: 50 nM (EC₅₀)

References

[1] P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. DOI:10.1021/jm9903601
[2] Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. DOI:10.1038/sj.bjp.0705232
[3] Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 DOI:10.1074/jbc.M106908200

GW 9578(247923-29-1)Related Product Information

• 2-[(4-METHYLPHENYL)THIO]PROPANOIC ACID
• GW 9578