Basic information Safety Supplier Related

ACOLBIFENE

Basic information Safety Supplier Related

ACOLBIFENE Basic information

Product Name:
ACOLBIFENE
Synonyms:
  • 2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
  • rac-Acolbifene
  • ACOLBIFENE
  • (Rac)-EM-652
  • 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
CAS:
151533-34-5
MF:
C29H31NO4
MW:
457.56
Mol File:
151533-34-5.mol
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ACOLBIFENE Chemical Properties

Boiling point:
651.5±55.0 °C(Predicted)
Density 
1.217±0.06 g/cm3(Predicted)
solubility 
DMSO: 100 mg/mL (218.55 mM)
pka
9.70±0.40(Predicted)
form 
Crystal
color 
Purple to purplish red
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ACOLBIFENE Usage And Synthesis

Description

The prodrug EM-800 is an orally active nonsteroidal anties trogen and is a triphenylethylene rigid analogue. EM-800 undergoes ester hydrolysis to the active m etabolite acolbifene. This fourth-generation antiestrogen is 200-fold more potent than tam oxifen in breast and uterine cancer cells and is effective in patients for whom tamoxifen therapy has failed. The mechanistic rationale for the effectiveness of acolbifene in tamoxifen-resistant tumors is based on the fact that it inhibits both the AF-1 and AF-2 activation pathways and does not poss ess any intrinsic estrogenic action. Acolbifene enjoys a 60% breast cancer cure rate. Structurally, acolbifene resembles raloxifene, with a benzopyran ring substituted for the benz othiophene ring. An additional benefit observed with acolbifene is its protective effect on bone loss. Adverse effects include nausea and vomiting.

Uses

rac-Acolbifene is a reacemic compound of Acolbifene (A190230) which is a selective estrogen receptor modulator (SERM) acting as pure antiestrogen. Acolbifene is also the orally active antiestrogen which is the most potent of the known antiestrogens and exerts pure antiestrogenic activity in the mammary gland and endometrium.

ACOLBIFENESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
SPIRO PHARMA
Tel
Email
eric_feng1954@126.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
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ACOLBIFENE(151533-34-5)Related Product Information