5-[[[3-(4,4-DIPHENYL-1-PIPERIDINYL)PROPYL]AMINO]CARBONYL]-1,4-DIHYDRO-2,6-DIMETHYL-4-(4-NITROPHENYL)-3-PYRIDINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties

Boiling point:

780.3±60.0 °C(Predicted)

Density 

1.198±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

<64.52mg/ml in DMSO; <64.52mg/ml in ethanol

pka

14.77±0.70(Predicted)

5-[[[3-(4,4-DIPHENYL-1-PIPERIDINYL)PROPYL]AMINO]CARBONYL]-1,4-DIHYDRO-2,6-DIMETHYL-4-(4-NITROPHENYL)-3-PYRIDINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Usage And Synthesis

Uses

SNAP 5089 is an a1c adrenergic receptor antagonist.

Biological Activity

Subtype-selective α 1A -adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (K i values are 0.35, 220, 370, 540, 800 and 1200 nM for α 1A , α 1B , α 2C , α 1D , α 2B and α 2A subtypes respectively and 540 nM for L-type Ca 2+ channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.

5-[[[3-(4,4-DIPHENYL-1-PIPERIDINYL)PROPYL]AMINO]CARBONYL]-1,4-DIHYDRO-2,6-DIMETHYL-4-(4-NITROPHENYL)-3-PYRIDINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(157066-76-7)Related Product Information

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• 5-[[[3-(4,4-DIPHENYL-1-PIPERIDINYL)PROPYL]AMINO]CARBONYL]-1,4-DIHYDRO-2,6-DIMETHYL-4-(4-NITROPHENYL)-3-PYRIDINECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE