6-METHOXYISOQUINOLIN-1-OL Chemical Properties

Melting point:

180 °C

Boiling point:

438.5±45.0 °C(Predicted)

Density 

1.199±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

12.79±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C10H9NO2/c1-13-8-2-3-9-7(6-8)4-5-11-10(9)12/h2-6H,1H3,(H,11,12)

InChIKey

DDLJWWYULDUBGA-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=C(OC)C=C2)C=CN1

Safety Information

HS Code 

2933499090

6-METHOXYISOQUINOLIN-1-OL Usage And Synthesis

Synthesis

Step 1: Ethyl chloroformate (~1.5 eq.) was added slowly and dropwise to a solution of acetone (80 mL) containing 3-methoxycinnamic acid (11.0 g, 62 mmol) and triethylamine (12.5 g, 124 mmol) at 0 °C. After maintaining the reaction at this temperature for 1 hour, aqueous NaN3 (6.40 g, 100 mmol dissolved in 35 mL H2O) was added dropwise and the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, water (100 mL) was added and volatiles were removed under vacuum. The reaction mixture was extracted with toluene (3 x 50 mL) and the organic layers were combined, dried with MgSO4 and filtered. The filtrate was slowly added dropwise to a preheated mixture of diphenylmethane (50 mL) and tributylamine (30 mL), and toluene was removed by distillation during the dropwise addition. After the dropwise addition, the reaction temperature was raised to 210 °C and maintained for 2 hours. At the end of the reaction, the mixture was cooled, the precipitated product was collected by filtration, washed with hexane (2 x 50 mL) and dried to give 6-methoxyisoquinolin-1(2H)-one as a white solid (5.53 g, 51% yield) (Ref. Nicolas Briet et al., Tetrahedron, 2002, 5761-5766).LC-MS Analysis showed MS m/z 176 (M++H).

References

[1] Patent: US2009/285773, 2009, A1. Location in patent: Page/Page column 12
[2] Patent: WO2005/46712, 2005, A1. Location in patent: Page/Page column 57; 58
[3] Patent: US2005/143316, 2005, A1. Location in patent: Page/Page column 34
[4] Patent: US2013/115190, 2013, A1
[5] Patent: US2015/376233, 2015, A1

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