1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride Basic information
- Product Name:
- 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride
- Synonyms:
-
- 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride
- MCOPPB trihydrochloride
- MCOPPB
- 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole
- 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
- MCOPPB trihydrochloride hydrate
- 1-(1-(1-Methylcyclooctyl)piperidin-4-yl)-2-(piperidin-3-yl)-1H-Benzo[d]imidazole trihydrochlor
- 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[(3R)-piperidin-3-yl]benzimidazole
- CAS:
- 1028969-49-4
- MF:
- C26H40N4
- MW:
- 408.62
- Mol File:
- 1028969-49-4.mol
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1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride Chemical Properties
- Melting point:
- >249°C (dec.)
- Boiling point:
- 576.5±50.0 °C(Predicted)
- Density
- 1.18
- storage temp.
- Store at -20°C
- solubility
- H2O: ≥13mg/mL
- form
- powder
- pka
- 9.67±0.10(Predicted)
- color
- white to tan
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1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochloride Usage And Synthesis
Uses
A potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazoletrihydrochlorideSupplier
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