N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Chemical Properties

Density 

1.270

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

H2O: soluble15mg/mL, clear

form 

powder

pka

15.94±0.20(Predicted)

color 

white to light brown

Water Solubility 

H2O: 15mg/mL, clear

InChIKey

UKBGBACORPRCGG-UHFFFAOYSA-N

SMILES

C1(C(NCCCNC2C(C3CC3)=CN=C(NC3=CC=CC(CN4CCOCC4)=C3)N=2)=O)CCC1

Safety Information

WGK Germany 

3

Storage Class

11 - Combustible Solids

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Usage And Synthesis

Uses

MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.

Definition

ChEBI: N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide is an aromatic amine.

Biochem/physiol Actions

MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.

target

IKKe