ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > INCB 3284 diMesylate
INCB 3284 diMesylate
INCB 3284 diMesylate Basic information
- Product Name:
- INCB 3284 diMesylate
- Synonyms:
-
- INCB 3284 diMesylate
- INCB3284
- INCB 3284 biMesylate
- N-[2-({(3R)-1-[trans-4-Hydroxy-4-(6-Methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl}aMino)-2-oxoethyl]-3-(trifluoroMethyl)benzaMide Methanesulfonate (1:2)
- Dimesylate
- INCB 3284 dimesylate, >=98%
- N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide,methanesulfonic acid
- N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
- CAS:
- 887401-93-6
- MF:
- C26H31F3N4O4
- MW:
- 520.5439496
- Mol File:
- 887401-93-6.mol
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INCB 3284 diMesylate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF:11.0(Max Conc. mg/mL);15.43(Max Conc. mM)
DMSO:57.19(Max Conc. mg/mL);80.24(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);7.02(Max Conc. mM)
Water:71.28(Max Conc. mg/mL);100.0(Max Conc. mM) - form
- Powder
- color
- Colorless to light yellow
- InChIKey
- PNPNUHKICDECDH-SEBNIYPMSA-N
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INCB 3284 diMesylate Usage And Synthesis
Uses
Dimesylate is a potent, selective, and orally bioavailable hCCR2 antagonist.
Biological Activity
Primary Target
human CCR2 (hCCR2)', 'Target IC50: 3.7 nM, 4.7 nM, and 84 nM for different assays.
in vivo
INCB 3284 (1 mg/kg/day, ip) reduces liver damage, and decreases microglia activation in AOM-treated mice via inhibition on CCR2. INCB 3284 also significantly reduces the pERK1/2 to tERK1/2 ratio, as well as G-protein signaling pathway activity and proinflammatory cytokine production in cortex lysates from mice administed with azoxymethane[2].
IC 50
MCP-1-hCCR2: 3.7 nM (IC50)
storage
Store at -20°C
INCB 3284 diMesylateSupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
China Langchem Inc.
- Tel
- 0086-21-58956006
NCE Biomedical Co.,Ltd.
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn