N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide Chemical Properties

Density 

1.308±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.2 mg/ml

form 

A solid

pka

9.97±0.70(Predicted)

N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide Usage And Synthesis

Uses

DGAT-1 inhibitor 3 (compound 10) is a potent DGAT-1 inhibitor with an IC50 value of 0.038 μM. DGAT-1 inhibitor 3 has the potential for the research of obesity and diabetes[1].

References

[1] Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46. DOI:10.1021/jm101580m

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