5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine Basic information
- Product Name:
- 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine
- Synonyms:
-
- Desmethyl-VS-5584
- 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine
- 5-[9-(1-Methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine
- 5-[2-(morpholin-4-yl)-9-(propan-2-yl)-9H-purin-6-yl]pyrimidin-2-amine
- DESMETHYL VS 5584; DESMETHYL VS5584
- 2-Pyrimidinamine, 5-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-
- VS-5584 analog
- Desmethyl-SB2343,Dual inhibitor,Selectivity,DesmethylVS5584,Mammalian target of Rapamycin,PI3K,Phosphoinositide 3-kinase,mTOR,Inhibitor,Desmethyl VS 5584,inhibit
- CAS:
- 1246535-95-4
- MF:
- C16H20N8O
- MW:
- 340.38
- Mol File:
- 1246535-95-4.mol
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5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine Chemical Properties
- Boiling point:
- 669.3±65.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform: 0.5mg/mL
- form
- A solid
- pka
- 3.94±0.10(Predicted)
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5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine Usage And Synthesis
Description
VS-5584 analog is a dual inhibitor of PI3Kα and mammalian target of rapamycin (mTOR; IC50s = 17 and 150 nM, respectively). It is a desmethyl analog of the dual PI3K/mTOR inhibitor VS-5584 .
Uses
An intermediate in the preparation of purine compounds as therapeutic kinase inhibitors.
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