2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- CAS#: 875787-07-8

ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > 2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-

2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-

Basic information Safety Supplier Related

2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Basic information

Product Name:

2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-

Synonyms:

2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-
LXR623
2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
WAY 252623
2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-
2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole WAY 252623
LXR623/LXR-623
LXR-623 (WAY-252623)

CAS:

875787-07-8

MF:

C21H12ClF5N2

MW:

422.78

Product Categories:

Inhibitor
Inhibitors
API

Mol File:

875787-07-8.mol

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2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Chemical Properties

Melting point:: 93℃
Boiling point:: 528.4±50.0 °C(Predicted)
Density: 1.40
storage temp.: room temp
solubility: DMSO:50.0(Max Conc. mg/mL);118.26(Max Conc. mM)
Ethanol:52.0(Max Conc. mg/mL);123.0(Max Conc. mM)
pka: -1.87±0.30(Predicted)
form: powder
color: white to beige
InChI: 1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
InChIKey: KYWWJENKIMRJBI-UHFFFAOYSA-N
SMILES: FC(F)(F)c1c2n[n](c(c2ccc1)c4ccc(cc4)F)Cc3c(cc(cc3)F)Cl

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Safety Information

RIDADR: UN 2811 6.1 / PGIII
WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Usage And Synthesis

Uses

WAY 252623 is a novel and potent LXR (liverX receptor) β-agonist used as a potential candidate for the treatment of atopic dermatitis.

Biochem/physiol Actions

WAY-252623 (LXR623) is an orally available, potent and highly selective Liver X receptors (LXRs) agonist that significantly reduced total and LDL-cholesterol. WAY-252623 reduces lesion progression in the murine LDLR(-/-) atherosclerosis model.

in vivo

LXR-623 (400 mg/kg, p.o.) crosses the blood-brain barrier, induces target gene expression, and achieves therapeutic levels in GBM cells in the brain with minimal activity in the periphery. LXR-623 inhibits tumor growth, promotes tumor cell death, and prolongs the survival of mice bearing intracranial patient-derived GBMs^[1]. LXR-623 (1.5, 5 mg/kg/day) significantly reduces progression of atherosclerosis in animals compared with the placebo group^[2]. WAY-252623 (15 and 50 mg/kg) results in a significant reduction of atherosclerosis in a dose-dependent manner. WAY-252623 (20, 60, and 120 mg/kg/day, p.o.) displays neutral lipid effects in this CETP-expressing Syrian hamster^[3]. Moreover, LXR-623 (50 mg/kg) induces gene expression in rodent peripheral blood cells in rat. LXR-623 (0, 15 and 50 mg/kg) dose-dependently upregulates transcription of ABCA1 and ABCG1 in monkey whole blood cells proportional to dose^[4].

storage

Store at +4°C

2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-Supplier

Shanghai Boyle Chemical Co., Ltd.

Tel
Email: sales@boylechem.com

shanghai Rainbow MediTech.Co.Ltd.

Tel: 021-64968085,64968086-5815,5812; 13472757003
Email: xiaoxia.zeng@rainbowpharma.cn

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Email: info@sagechem.com

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Email: info@chemexpress.com

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