(1-PALMITOYL)-L-ALPHA-LYSOPHOSPHATIDIC ACID NA Chemical Properties

solubility 

DMF: 2 mg/ml
DMSO: 2.5 mg/ml
Ethanol: 25 mg/mlPBS (pH 7.2): 3 mg/ml

form 

Solid

color 

White to off-white

(1-PALMITOYL)-L-ALPHA-LYSOPHOSPHATIDIC ACID NA Usage And Synthesis

Uses

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is an endogenous metabolite. 1-Palmitoyl-sn-glycerol 3-phosphate can be used for the research of non‐alcoholic fatty liver disease[1].

Definition

ChEBI: 1-palmitoyl-sn-glycerol 3-phosphate is a 1-acyl-sn-glycerol 3-phosphate having palmitoyl as the acyl group. It is a 1-acyl-sn-glycerol 3-phosphate and a 1-palmitoylglycerol 3-phosphate. It is a conjugate acid of a 1-palmitoyl-sn-glycerol 3-phosphate(2-).

References

[1] Chalasani N, et al. Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2018 Jun;47(12):1639-1651. DOI:10.1111/apt.14674
[2] KYOKO NOGUCHI  Takao S  Satoshi Ishii. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.[J]. The Journal of Biological Chemistry, 2003, 278 28: 25600-25606. DOI: 10.1074/jbc.m302648200
[3] MOOLENAAR W H. LPA: a novel lipid mediator with diverse biological actions.[J]. Trends in Cell Biology, 1994, 4 6: 213-219. DOI: 10.1016/0962-8924(94)90144-9
[4] K A KROGFELT. Specific phospholipids enhance the activity of beta-lactam antibiotics against Pseudomonas aeruginosa.[J]. Journal of Antimicrobial Chemotherapy, 2000, 46 3: 377-384. DOI: 10.1093/jac/46.3.377

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