(1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE
(1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE Basic information
- Product Name:
- (1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE
- Synonyms:
-
- (1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE
- 1-phenylpropylene oxide
- [(2R,3R)-3-Methyloxiranyl]benzene
- [2R,3R,(+)]-3-Methyl-2-phenyloxirane
- (1R,2R)-(+)-1-Phenylpropylene oxide 97%
- (1,2-epoxypropyl)-,(1r,2r)-benzen
- (1r,2r)-(+)-1-phenyl-1,2-epoxypropane
- (2r-trans)-oxiran
- CAS:
- 14212-54-5
- MF:
- C9H10O
- MW:
- 134.18
- Product Categories:
-
- EPOXYDE
- Mol File:
- 14212-54-5.mol
(1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE Chemical Properties
- Boiling point:
- 201-207 °C(lit.)
- Density
- 1.006 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.518(lit.)
- Flash point:
- 156 °F
- optical activity
- [α]20/D +110°, neat
MSDS
- Language:English Provider:SigmaAldrich
(1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE Usage And Synthesis
Synthesis
A solution of 0.05 M Na2HPO4 (10.0 mL) was added to a 25-mL solution of undiluted commercial household bleach (Clorox). The pH of the resulting buffered solution (0.55 M in NaOCl) was adjusted to pH 11.3 by addition of a few drops of 1 M NaOH solution. This solution was cooled to 0 °C and then added at once to a 0 °C solution of the manganese catalyst (260 mg, 0.4 mmol) and cis-o-methylstyrene (1.18 g, 10 mmol) in 10 mL of CH2Cl2. The two-phase mixture was stirred at room temperature, and the reaction progress was monitored by TLC. After 3 h, 100 mL of hexane was added to the mixture and the brown organic phase was separated, washed twice with 100 mL of H2O and once with 100 mL of saturated NaCl solution, and then dried (Na2SO4). After solvent removal, the residue was purifified by flflash chromatography on silica gel to afford the epoxide (0.912 g, 68%). The ee of the epoxide was determined to be 84% by 1 H NMR analysis in the presence of Eu(hfc)3.
Reference: Zhang, W.; Jacobsen, E. N. J. Org. Chem. 1991, 56, 2296−2298.
Uses
Chiral building block. Tool for studying enzyme hydrolysis rates.
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(1R,2R)-(+)-1-PHENYLPROPYLENE OXIDE(14212-54-5)Related Product Information
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