A 967079 Chemical Properties

Boiling point:

324.4±34.0 °C(Predicted)

Density 

1.03±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

solubility 

DMSO: ≥12mg/mL

pka

12.23±0.40(Predicted)

form 

powder

color 

white to tan

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months

Safety Information

WGK Germany 

3

HS Code 

2928009090

A 967079 Usage And Synthesis

Description

A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable

Uses

A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Uses

(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.

General Description

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Biochem/physiol Actions

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

storage

+4°C

References

1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.

A 967079(1170613-55-4)Related Product Information

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