2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Chemical Properties

Boiling point:

458.7±33.0 °C(Predicted)

Density 

1.358±0.06 g/cm3(Predicted)

storage temp. 

RT

solubility 

Soluble in DMSO (up to 25 mg/ml).

form 

solid

pka

4.07±0.10(Predicted)

color 

White

Stability:

Stable for 1 year from date of pruchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

2-Propenoic acid, 3,3'-(1,3-phenylene)bis- Usage And Synthesis

Description

CVPA (37710-81-9) is an aquaporin-1 inhibitor (IC50 = 8.1 μM) discovered by molecular docking against the extracellular domain of human aquaporin-1 followed by experimental testing in a Xenopus oocyte swelling assay.1

Uses

TC AQP1 1 is a human aquaoporin-1 (hAQP1) selective inhibitor and is considered to have therapeutic potential towards the potential treatment of glaucoma, brain edema, inflammatory pain and certain types of cancer.

storage

Store at +4°C

References

[1] DANIEL SEELIGER. Discovery of Novel Human Aquaporin-1 Blockers[J]. ACS Chemical Biology, 2012, 8 1: 249-256. DOI:10.1021/cb300153z

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