JNK inhibitor Chemical Properties

Density 

1.301±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

form 

solid

pka

13.34±0.70(Predicted)

color 

White to gray

Safety Information

HS Code 

2933998090

JNK inhibitor Usage And Synthesis

Description

JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC₅₀s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC₅₀s = 130 and 244 nM, respectively).

Uses

JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.

IC 50

JNK3: 0.7 nM (IC₅₀); JNK1: 1.5 nM (IC₅₀); JNK2: 2 nM (IC₅₀)

References

[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46.