CID 797718 Chemical Properties

Melting point:

213-216 °C(Solv: isopropanol (67-63-0))

Boiling point:

517.6±50.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml

form 

A crystalline solid

pka

9.39±0.20(Predicted)

color 

Light brown to brown

CID 797718 Usage And Synthesis

Description

CID797718 is a protein kinase D1 (PKD1) inhibitor (IC₅₀ = 7 μM). It also inhibits CDK activating kinase (CAK) and polo-like kinase 1 (PLK1) but has no activity at AKT (IC₅₀s = 8.4, 21.9, and >50 μM, respectively). CID797718 inhibits PKD1 activity in LNCaP cells with an IC₅₀ value of 0.21 μM. CID797718 is a byproduct in the synthesis of CID755673 .

Uses

CID-797718 is a compound with ambiguous properties.

References

[1] ELIZABETH R SHARLOW. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.[J]. The Journal of Biological Chemistry, 2008, 283 48: 33516-33526. DOI: 10.1074/jbc.m805358200
[2] COURTNEY R LAVALLE. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.[J]. BMC chemical biology, 2010, 10: 5. DOI: 10.1186/1472-6769-10-5