4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Chemical Properties

Boiling point:

319.1±42.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

pka

0.63±0.10(Predicted)

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Usage And Synthesis

Synthesis

A solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine (70 g, 322.61 mmol) in THF (1.4 L) was treated with a solution of ethanolamine (32 g, 709.74 mmol, 46.37 mL) in THF (100 mL) at 0°C, dropwise under N2, over 1 hour. Once the addition was complete, the mixture was stirred at 25°C for 1 hour. The mixture was then filtered and concentrated under reduced pressure to obtain a residue. The residue was subsequently triturated with DCM (200 mL) and filtered. The filtrate was recrystallized with a mixture of n-heptane (600 mL) and MTBE (400 mL). The resulting phase was syrup-like in consistency, and the liquid phase was discarded. The syrup residue was further purified by silica gel column chromatography (PE: EtOAc=20:1) to yield 4-chloro-N-ethyl-5-(trifluoromethyl) pyrimidine-2-amine as a white solid.

4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine(1374829-47-6)Related Product Information

• 2-chloro-N-cyclopropyl-5-iodopyrimidine-4-amine
• 2-CHLORO-N-METHYL-5-(TRIFLUOROMETHYL)PYRIMIDIN-4-AMINE
• 2-Chloro-N-cyclopropyl-5-(trifluoroMethyl)pyriMidin-4-aMine
• 2-CHLORO-5-IODO-N-METHYLPYRIMIDIN-4-AMINE
• 2-Chloro-N-ethyl-5-iodopyrimidin-4-amine