RDEA-594 sodiuM
RDEA-594 sodiuM Basic information
- Product Name:
- RDEA-594 sodiuM
- Synonyms:
-
- Lesinurad sodiuM
- RDEA-594 sodiuM
- Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)
- sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate
- Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt
- Sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3- yl)sulfanyl)acetate
- CS-651
- Pentanedioicacid,5-oxo-,diethylester
- CAS:
- 1151516-14-1
- MF:
- C17H13BrN3O2S.Na
- MW:
- 426.26279
- Mol File:
- 1151516-14-1.mol
RDEA-594 sodiuM Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:55.5(Max Conc. mg/mL);137.97(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);199.41(Max Conc. mM)
Water:8.0(Max Conc. mg/mL);18.77(Max Conc. mM) - form
- Solid
- color
- White to off-white
RDEA-594 sodiuM Usage And Synthesis
Uses
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
in vivo
Lesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806[3].
References
[1] Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52 DOI:10.1037//0882-7974.4.4.471
[2] Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59. DOI:10.1177/1759720X16646703
[3] L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake ,shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.
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