CK-0157869 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

color 

white to light gray

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

61

WGK Germany 

3

CK-0157869 Usage And Synthesis

Description

CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC₅₀ value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.

Uses

CK-869 has been used as an Arp2/3 complex inhibitor:

• to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
• to induce membrane blebbing in HT1080 fibrosarcoma cells
• to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Uses

CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-0157869(388592-44-7)Related Product Information

• CK-636