CK-636
CK-636 Basic information
- Product Name:
- CK-636
- Synonyms:
-
- CK-636
- N-(2-(2-METHYL-1H-INDOL-3-YL)ETHYL)THIOPHENE-2-CARBOXAMIDE
- N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
- CK-636, >=98%
- CK-0944636
- CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
- N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636
- CK-636;CK636; CK 636
- CAS:
- 442632-72-6
- MF:
- C16H16N2OS
- MW:
- 284.38
- EINECS:
- 200-256-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 442632-72-6.mol
CK-636 Chemical Properties
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- peach to light tan
- InChIKey
- ACAKNPKRLPMONU-UHFFFAOYSA-N
- CAS DataBase Reference
- 442632-72-6
CK-636 Usage And Synthesis
Description
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
In vitro
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
Uses
CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization.
CK-636Supplier
- Tel
- 0086-21-58956006
- Products Intro
- Product Name:CK-636
CAS:442632-72-6
Purity:98% Package:1KG;10KG
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- 0411-62910999 13889544652
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- Products Intro
- Product Name:CK636;CK-0944636
CAS:442632-72-6
Purity:>98%,BR Package:10MG;50MG; Remarks:MB4098
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- 025-66099280 17798518460
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- Products Intro
- Product Name:CK-636
CAS:442632-72-6
Purity:95% Package:1g;5g;10g
- Tel
- 021-58950125
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- Products Intro
- Product Name:CK-636
CAS:442632-72-6
Purity:>98% Package:837RMB/10mg
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Products Intro
- Product Name:CK-636
CAS:442632-72-6
Purity:>98% Package:837RMB/10mg