Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  PI3K / Akt / mTOR >  PI3K inhibitor >  LY 294002 HYDROCHLORIDE

LY 294002 HYDROCHLORIDE

Basic information Safety Supplier Related

LY 294002 HYDROCHLORIDE Basic information

Product Name:
LY 294002 HYDROCHLORIDE
Synonyms:
  • LY 294002
  • LY 294002 HYDROCHLORIDE
  • 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE
  • 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • CS-1859
  • LY294002 (HCl Salt)
CAS:
154447-36-6
MF:
C19H17NO3
MW:
307.34
EINECS:
1312995-182-4
Product Categories:
  • PI3K/Akt Signaling
  • Inhibitors
  • Inhibitor
  • Anti-cancer&immunity
  • PI3K/Akt/mTOR
  • Akt
  • Lipid signaling
  • Signalling
  • Cell Cycle Regulation
  • apis
  • mTOR
  • PI3K
Mol File:
154447-36-6.mol
More
Less

LY 294002 HYDROCHLORIDE Chemical Properties

Melting point:
183-185℃
Boiling point:
494.6±45.0 °C(Predicted)
Density 
1.266
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: >5 mg/mL
form 
solid
pka
0.55±0.20(Predicted)
color 
white to off-white
Water Solubility 
Soluble in DMSO at 5mg/ml. Insoluble in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
CAS DataBase Reference
154447-36-6
More
Less

Safety Information

Safety Statements 
24-25
WGK Germany 
3
HS Code 
29349990

MSDS

More
Less

LY 294002 HYDROCHLORIDE Usage And Synthesis

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Uses

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

target

p110α

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

LY 294002 HYDROCHLORIDESupplier

Zhengzhou HSH Science & Technology Co., Ltd. Gold
Tel
0371-55932928 18937192232
Email
1282296214@qq.com
TargetMol Chemicals Inc. Gold
Tel
021-021-33632979 15002134094
Email
marketing@targetmol.com
Nanjing Tengyi Biotechnology Co., Ltd Gold
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com