LY 294002 HYDROCHLORIDE
LY 294002 HYDROCHLORIDE Basic information
- Product Name:
- LY 294002 HYDROCHLORIDE
- Synonyms:
-
- LY 294002
- LY 294002 HYDROCHLORIDE
- 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
- 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
- 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE
- 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
- CS-1859
- LY294002 (HCl Salt)
- CAS:
- 154447-36-6
- MF:
- C19H17NO3
- MW:
- 307.34
- EINECS:
- 1312995-182-4
- Product Categories:
-
- PI3K/Akt Signaling
- Inhibitors
- Inhibitor
- Anti-cancer&immunity
- PI3K/Akt/mTOR
- Akt
- Lipid signaling
- Signalling
- Cell Cycle Regulation
- apis
- mTOR
- PI3K
- Mol File:
- 154447-36-6.mol
LY 294002 HYDROCHLORIDE Chemical Properties
- Melting point:
- 183-185℃
- Boiling point:
- 494.6±45.0 °C(Predicted)
- Density
- 1.266
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: >5 mg/mL
- form
- solid
- pka
- 0.55±0.20(Predicted)
- color
- white to off-white
- Water Solubility
- Soluble in DMSO at 5mg/ml. Insoluble in water
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
- InChIKey
- CZQHHVNHHHRRDU-UHFFFAOYSA-N
- CAS DataBase Reference
- 154447-36-6
Safety Information
- Safety Statements
- 24-25
- WGK Germany
- 3
- HS Code
- 29349990
MSDS
- Language:English Provider:SigmaAldrich
LY 294002 HYDROCHLORIDE Usage And Synthesis
Description
LY294002 is a selective phosphatidylinositol 3-
Uses
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).
Uses
A potent blocker of PI 3-kinase/Akt signaling.
Uses
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.
Uses
LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.
Definition
ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Biological Activity
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .
target
p110α
References
1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241
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