Basic information Safety Supplier Related

LY3214996

Basic information Safety Supplier Related

LY3214996 Basic information

Product Name:
LY3214996
Synonyms:
  • LY3214996
  • 6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one
  • CS-2495
  • 4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-
  • Temuterkib
  • Temuterkib (LY3214996)
  • LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK
  • LY-3214996 (LY3214996)
CAS:
1951483-29-6
MF:
C22H27N7O2S
MW:
453.56
Mol File:
1951483-29-6.mol
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LY3214996 Chemical Properties

Boiling point:
711.5±70.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM)
form 
A crystalline solid
pka
6.58±0.10(Predicted)
color 
White to yellow
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Safety Information

HS Code 
2934999090
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LY3214996 Usage And Synthesis

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

LY3214996Supplier

Suzhou Chenrui Biotechnology Co. LTD Gold
Tel
17625585511
Email
1580084073@qq.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
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