E 7010 Chemical Properties

Melting point:

162 °C(dec.)

Boiling point:

551.0±60.0 °C(Predicted)

Density 

1.427

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic

form 

powder to crystal

pka

7.86±0.40(Predicted)

color 

White to Yellow to Orange

Safety Information

RTECS 

DB2734000

HS Code 

2935.90.9500

E 7010 Usage And Synthesis

Description

ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (K_i = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC₅₀s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.

Definition

ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.

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