- Product Name:
- Vincristine sulfate
- VINCRISTINE SULFATE
- VINCRISTINE SULFATE, APOCYNACEAE SPECIES
- VINCRISTINE SULFATE SALT
- VINCRISTINE SULPHATE
- VCR, LEUKOCRISTINE SULFATE
- VCR SULFATE
- Product Categories:
- Chiral Reagents
- VINCRISTINE SULPHATE
- Intermediates & Fine Chemicals
- Additional Affinity PurificationRecombinant Protein Expression and Analysis
- Plant Proteomics
- Protein Purification
- Purification and Detection
- Anti-cancer & immunity
- chemical reagent
- pharmaceutical intermediate
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
Vincristine sulfate Chemical Properties
- Melting point:
- 300 °C
- D26 +8.5° (c = 0.8)
- Boiling point:
- 273-281 °C
- storage temp.
- methanol: soluble20mg/mL
- lyophilized powder
- white to off-white
- Water Solubility
- >=1 g/100 mL at 24 ºC
- 3 (Vol. 26, Sup 7) 1987
- EPA Substance Registry System
- Vincristine sulfate (2068-78-2)
Vincristine sulfate Usage And Synthesis
Oncovin,Lilly ,US ,1963
Vincristin sulfate USP (Oncovin) is used to treat acute leukemia in children; lymphocytic leukemia; Hodgkin’s disease; non-Hodgkin’s lymphomas; Wilm’s tumor; neuroblastoma; rhabdomyosarcoma.
An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.
The alkaloid mixture from the extraction of Vinca rosea plants (as in
vinblastine extraction) was chromatographed to give vincristine which was
then converted to the sulfate, according to US Patent 3,205,220.
Vincristine may also be prepared in a semisynthetic process starting from vinblastine. Vinblastine or a salt thereof, preferably the sulfate, is oxidized with chromic acid or with one of its salts at a low temperature, the reaction mixture is neutralized or rendered alkaline and the product is separated therefrom by extraction, the extract is evaporated to dryness, the dry residue is optionally formylated, vincristine, and optionally N-demethylvinblastine also, are isolated from the product, and the product(s) are optionally converted into their salts; preferably into the sulfates, according to US Patent 3,899,493.
Oncovin (Lilly); Vincasar (Sicor).
Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours. The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.
An anticancer drug. White to slightly yellow, amorphous or crystalline powder. Sensitive to light. Odorless. pH (0.1% solution) 3.5 - 4.5.
Air & Water Reactions
Very hygroscopic. Water soluble.
Sensitive to hydrolysis, oxidation and heat. Incompatible with strong oxidizing agents. .
Flash point data for Vincristine sulfate are not available; however, Vincristine sulfate is probably combustible.
Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.
Veterinary Drugs and Treatments
Vincristine is used as an antineoplastic primarily in combination
drug protocols in dogs and cats in the treatment of lymphoid and
hematopoietic neoplasms. In dogs, it may be used alone in the therapy
of transmissible venereal neoplasms.
Because vincristine can induce thrombocytosis (at low doses) and has some immunosuppressant activity, it may also be employed in the treatment of immune-mediated thrombocytopenia.
The salt is recrystallised from MeOH. It has UV max at 220, 255 and 296nm (log 4.65, 4.21 and 4.18). It is a monoamine oxidase inhibitor and is used in cancer research [Son et al. J Med Chem 33 1845 1990, Horio et al. Proc Natl Acad Sci USA 85 3580 1988].
Vincristine sulfate Preparation Products And Raw materials
- 010-82848833- ;010-82848833-
- Vinblastine sulfate
- VINCRISTINE SULFATE, [3H]-
- Vindesine sulfate
- n-Dodecyl alcohol, sulfated
- Zinc sulphate
- Copper(II) sulfate
- Aluminum sulfate
- Ammonium sulfate
- Zinc sulfate heptahydrate
- Sodium sulfate
- Sodium dodecyl sulfate
- Magnesium sulfate heptahydrate
- Ammonium lauryl sulfate
- Dimethyl sulfate
- calcium sulfate