Basic information Safety Supplier Related

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID

Basic information Safety Supplier Related

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Basic information

Product Name:
(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID
Synonyms:
  • TPMPA
  • (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID
  • (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID HYDRATE
  • tpmpa hydrate
  • MFUKVPOVVKKLRQ-UHFFFAOYSA-N
  • 3,6-dihydro-2H-pyridin-1-ylium-4-yl(methyl)phosphinate
  • Phosphinic acid, P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-
CAS:
182485-36-5
MF:
C6H12NO2P
MW:
161.14
Product Categories:
  • GABA/Glycine receptor
Mol File:
182485-36-5.mol
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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Chemical Properties

Melting point:
252-254°
Boiling point:
417.2±45.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
H2O: 16 mg/mL
form 
solid
pka
1.97±0.20(Predicted)
color 
white or off-white
Water Solubility 
Soluble to 100 mM in water
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Safety Information

WGK Germany 
3
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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Usage And Synthesis

Uses

TPMPA is a selective, competitive GABAC antagonist with only minimal effects on GABAA and GABAB receptor.

Uses

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells.

Uses

Neurochemical tool.

Biological Activity

A selective, competitive GABA C antagonist with only minimal effects on GABA A and GABA B receptors (K b values are 2.1 μ M (antagonist), 320 μ M (antagonist) and EC 50 ~ 500 μ M (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ 1 receptors over ρ 2 receptors.

Biochem/physiol Actions

TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.

storage

Store at RT

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACIDSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
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orderCN@merckgroup.com
EMMX Biotechnology LLC
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888-539-0666
Email
info@emmx.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID(182485-36-5)Related Product Information