Visinin-like protein 1 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Storage Class

10 - Combustible liquids

Visinin-like protein 1 Usage And Synthesis

Uses

Anti-VILIP-1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biological Activity

Visinin-like protein-1 (VILIP-1) associates with the plasma membrane and Golgi membranes and modulates the signaling of cAMP and cGMP in neuronal cells. It upregulates the expression of functional α4β2 neuronal nicotinic acetylcholine receptors in hippocampal neurons. VILIP-1 modulates the activity of guanylyl cyclase B through clathrin dependent receptor cycling, supporting a role for VILIP-1 in membrane trafficking in the central nervous system (CNS). VILIP-1 is implicated in the pathology of CNS disorders including Alzheimerμs disease, schizophrenia and as a biomarker in ischemic stroke. VILIP-1 expression is regulated during induction of hippocampal synaptic plasticity, underlying learning and memory processes. Neuronal Ca2+ sensor (NCS) proteins are involved in a variety of Ca2+-dependent signal transduction processes in neurons.