ETHYL 3-METHYL-4-OXOCROTONATE Chemical Properties

Boiling point:

195-202 °C(lit.)

Density 

1.044 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.461

Flash point:

109 °C

storage temp. 

2-8°C

solubility 

Chloroform, Ether, Ethyl Acetate, Methanol

form 

Oil

color 

Clear Colourless to Light Yellow

BRN 

1704098

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36-26

WGK Germany 

3

F 

10

HS Code 

2918300090

MSDS

• Language:English Provider:SigmaAldrich

ETHYL 3-METHYL-4-OXOCROTONATE Usage And Synthesis

Chemical Properties

Light Yellow Oil

Uses

Derivative of monoenoic and trienoic analogs of Sorbic Acid with antifungal activity.

Synthesis

General procedure for the synthesis of ethyl 3-formyl-2-butenoate from ethyl (E)-4-hydroxy-3-methylbut-2-enoate: to a vigorously stirred solution of ethyl (E)-4-hydroxy-3-methylbut-2-enoate (9.37 g, 65 mmol) in dichloromethane (1.3 L) was added activated manganese dioxide powder (56.5 g, 650 mmol). The resulting suspension was stirred at room temperature for 1 hour and then filtered through a diatomaceous earth pad. The filtrate was evaporated to give pure ethyl 3-formyl-2-butenoate as a yellow oil. Yield: 7.66 g (92%); Thin Layer Chromatography (Spreading Agent D) Rf Value: 0.35; IR Spectra (pure sample, cm-1 ): 2829, 2740, 1718, 1660; GC-MS (electron bombardment, 20 eV): retention time = 4.82 min, mass-to-charge ratio (relative abundance): 142 (4, [M]+), 114 (15, [M- CO]+), 97 (100, [M-OCH2CH3]+), 96 (100, [M-CH3CH2OH]+); 1H nuclear magnetic resonance (CDCl3, δ): 9.54 (s, 1H), 6.49 (q, 1H, unresolved), 4.26 (q, 2H, J=6.8 Hz), 2.15 (d, 3H, J=1.2 Hz), and 1.33 (t, 3H, J=7.2Hz); 13C NMR (CDCl3, δ): 194.8, 165.7, 150.6, 135.8, 61.3, 14.4, 11.0.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 2, p. 721 - 737
[2] Synthesis, 1983, # 4, p. 297 - 300
[3] Journal of Organic Chemistry, 1986, vol. 51, # 2, p. 256 - 258

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