BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE Chemical Properties

Melting point:

169-172 °C(lit.)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Soluble in water

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solution Product May Develop Some Turbidity or Precipitate

color 

Slightly yellow to brown

BRN 

4724532

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3

HS Code 

29242990

MSDS

• Language:English Provider:SigmaAldrich

BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.

reaction suitability

reagent type: cross-linking reagent

Synthesis

General procedure for the synthesis of N-benzyloxycarbonyl ethylenediamine hydrochloride from N-Cbz-N'-Boc-ethylenediamine: benzyl tert-butyl ethane-1,2-dicarbamate (1.5 g, 6.3 mmol) was dissolved in methanol (10 mL) and HCl/EtOAc solution (2 mL) was added. The reaction mixture was stirred at room temperature for 10 h. After removal of the solvent by concentration, N-benzyloxycarbonyl ethylenediamine hydrochloride (1.0 g, 85% yield) was obtained.

References

[1] Bulletin of the Chemical Society of Japan, 1998, vol. 71, # 3, p. 699 - 709
[2] Journal of Peptide Science, 2013, vol. 19, # 1, p. 9 - 15
[3] Patent: WO2015/81282, 2015, A1. Location in patent: Paragraph 00712; 00713

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