Basic information Safety Supplier Related

Z-GLY-GLY-PHE-CHLOROMETHYLKETONE

Basic information Safety Supplier Related

Z-GLY-GLY-PHE-CHLOROMETHYLKETONE Basic information

Product Name:
Z-GLY-GLY-PHE-CHLOROMETHYLKETONE
Synonyms:
  • N-carbobenzyloxy-Gly-Gly-Phe chloromethyl ketone
  • Z-GLY-GLY-PHE-CHLOROMETHYLKETONE
  • Z-GLY-GLY-PHE-CMK
  • N-cbz-gly-gly-phe chloromethyl ketone
  • benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
  • Glycinamide, N-[(phenylmethoxy)carbonyl]glycyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-
  • Z-GGF-CMK
CAS:
35172-59-9
MF:
C22H24ClN3O5
MW:
445.9
Mol File:
35172-59-9.mol
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Z-GLY-GLY-PHE-CHLOROMETHYLKETONE Chemical Properties

Boiling point:
751.7±60.0 °C(Predicted)
Density 
1.281±0.06 g/cm3(Predicted)
storage temp. 
-15°C
pka
11.03±0.46(Predicted)
Sequence
{Cbz}-Gly-Gly-Phe-{CMK}
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Z-GLY-GLY-PHE-CHLOROMETHYLKETONE Usage And Synthesis

Uses

Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1].

References

[1] Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746. DOI:10.3389/fmicb.2017.00746

Z-GLY-GLY-PHE-CHLOROMETHYLKETONESupplier

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
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Z-GLY-GLY-PHE-CHLOROMETHYLKETONE(35172-59-9)Related Product Information