ANTI-E2F-3
ANTI-E2F-3 Basic information
- Product Name:
- ANTI-E2F-3
- Synonyms:
-
- ANTI-HUMAN E2F-3
- ANTI-E2F-3
- Monoclonal Anti-E2F3 antibody produced in mouse
- Anti-E2F transcription factor 3
- Anti-DKFZp686C18211
- Anti-KIAA0075
- Anti-MGC104598
- Anti-E2F3 antibody produced in rabbit
- MW:
- 0
- Product Categories:
-
- Alphabetical Index
- Antibodies for Gene Regulation and Expression
- Antibodies to Transcription FactorsAntibodies
- Cell Biology
- Clone Index
- EAntibodies
- P
- Mol File:
- Mol File
ANTI-E2F-3 Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
- biological source
- rabbit
MSDS
- Language:English Provider:SigmaAldrich
ANTI-E2F-3 Usage And Synthesis
Uses
Anti-E2F3 polyclonal antibody is used to tag E2F transcription factor 3 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of E2F transcription factor 3 in the regulation of cell growth, differentiation and cell death and as an oncogene.
Biological Activity
E2F3 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. E2F3 binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.