2-(2-AMINOPHENYL)PROPAN-2-OL Chemical Properties

Boiling point:

289℃

Density 

1.084

Flash point:

129℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

14.35±0.29(Predicted)

Appearance

Colorless to light yellow Viscous Liquid

Safety Information

HazardClass 

IRRITANT

2-(2-AMINOPHENYL)PROPAN-2-OL Usage And Synthesis

Synthesis

GENERAL STEPS: 1-(2-aminophenyl)ethanone (1.50 g, 11.1 mmol) was dissolved in tetrahydrofuran (11 mL) under argon protection and cooled at 0 °C. Subsequently, methylmagnesium bromide (1.0 mol/L tetrahydrofuran solution, 11.1 mL, 11.1 mmol) was added slowly. After addition, the reaction mixture was gradually warmed to room temperature and stirred. Upon completion of the reaction, the reaction was carefully quenched with saturated aqueous ammonium chloride solution. The reaction mixture was extracted with ethyl acetate (3 x 20 mL), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product obtained was a brown oil, which was purified by fast column chromatography to give 2-(2-aminophenyl)propan-2-ol as a light-colored oil (1.20 g, 72% yield).LC-MS analysis showed a retention time of 0.24 min, and m/z 134 ([M-OH]-) was observed in ESI+ mode.1H NMR (400 MHz, chloroform-d) δ ( ppm): 7.15 (d, 1H), 7.06 (t, 1H), 6.72 (t, 1H), 6.65 (d, 1H), 3.65 (br s, 1H), 1.67 (s, 6H).

References

[1] Patent: WO2018/17490, 2018, A1. Location in patent: Paragraph 0163; 0164
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 1, p. 189 - 192
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 47, p. 11486 - 11491

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