Basic information Safety Supplier Related

9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE

Basic information Safety Supplier Related

9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE Basic information

Product Name:
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE
Synonyms:
  • pgf2-alpha1,15-lactone
  • prosta-5,13-dien-1-oicacid,9,11,15-trihydroxy-,lambda-lactone,(5z,9-alpha,1
  • u47473
  • Prostaglandin F2α 1,15-lactone
  • 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE
  • PROSTAGLANDIN F2ALPHA 1,15-LACTONE
  • 13e,15s)-1-alph
  • (1R,3Z,10S,11E,13R,14R,16S)-14,16-dihydroxy-10-pentyl-9-oxabicyclo[11.3.0]hexadeca-3,11-dien-8-one
CAS:
55314-49-3
MF:
C20H32O4
MW:
336.47
Mol File:
55314-49-3.mol
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9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: >20.4 mg/ml; DMSO: >10 mg/ml; Ethanol: >105 mg/ml; Ethanol:PBS (30:70): 8 mg/ml; PBS (pH 7.2): <50 ug/ml
form 
A crystalline solid
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9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE Usage And Synthesis

Description

PGF 1,15-lactone is a lipid-soluble internal ester of PGF. Hydrolysis of the lactone readily produces free PGF in plasma. In rhesus monkeys, a total dose of 15 mg of PGF 1,15-lactone terminates early pregnancy, whereas PGF is ineffective.

Uses

PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey[1].

in vivo

PGF2α 1,15-lactone (5 mg for i.v.; 3 mg for intramuscularly) terminates early pregnancy in the monkey[1].

Animal Model:Rhesus monkey (trimester pregnant)[1]
Dosage:5 mg for i.v.; 3 mg for intramuscularly
Administration:IV on days 30 and 31, 31 and 32, or 33 and 34; Intramuscularly on days 29 and 30, 30 and 31, or 33 and 34
Result:Aborted between 36 and 48 hr after treatment, Within 10 minutes after treatment there was a significant increase in uterine tone and frequency of contractions.

References

[1] Spilman CH, et al. Effects of PGF2alpha and PGF2alpha, 1-15 lactone on the corpus luteum and on early pregnancy in the rhesus monkey. Prostaglandins. 1977 Sep;14(3):477-88. DOI:10.1016/0090-6980(77)90262-3

9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONESupplier

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