[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Chemical Properties

Boiling point:

442.2±55.0 °C(Predicted)

Density 

1.106±0.06 g/cm3(Predicted)

pka

2.06±0.70(Predicted)

[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Usage And Synthesis

Biological Activity

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester(1446282-35-4)Related Product Information

• [4-(Diethoxy-phosphorylamino)-butyl]-phosphoramidic acid diethyl ester
• [2-(Diethoxy-phosphorylamino)-ethyl]-phosphoramidic acid diethyl ester