N,N'-DICYCLOHEXYLUREA
N,N'-DICYCLOHEXYLUREA Basic information
- Product Name:
- N,N'-DICYCLOHEXYLUREA
- Synonyms:
-
- AURORA KA-3582
- n,n’-dicyclohexyl-ure
- N,N'-DICYCLOHEXYLUREA
- 1,3-DICYCLOHEXYLUREA
- N,N,-Dicyclohexylurea98.%
- Dicyclohexylcarbodiamide
- N,N'-Carbonylbis(cyclohexanamine)
- NSC 17013
- CAS:
- 2387-23-7
- MF:
- C13H24N2O
- MW:
- 224.34
- EINECS:
- 219-213-7
- Product Categories:
-
- Finasteride
- Carbonyl Compounds
- Organic Building Blocks
- Ureas
- Mol File:
- 2387-23-7.mol
N,N'-DICYCLOHEXYLUREA Chemical Properties
- Melting point:
- 232-233 °C(lit.)
- Boiling point:
- 408℃
- Density
- 1.02
- refractive index
- 1.4832 (estimate)
- Flash point:
- 158℃
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 13.89±0.20(Predicted)
- form
- Liquid
- color
- Clear
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)
- InChIKey
- ADFXKUOMJKEIND-UHFFFAOYSA-N
- SMILES
- N(C1CCCCC1)C(NC1CCCCC1)=O
- CAS DataBase Reference
- 2387-23-7(CAS DataBase Reference)
- EPA Substance Registry System
- N,N'-Dicyclohexylurea (2387-23-7)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
N,N'-DICYCLOHEXYLUREA Usage And Synthesis
Chemical Properties
white crystalline powder
Uses
N,N''-Dicyclohexylurea,is a substituted Urea (U822500) compound, which has shown to be a potent inhibitor of juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm M. sexta. Lomustine USP Related Compound C.
Definition
ChEBI: 1,3-dicyclohexylurea is a member of ureas.
Preparation
An excess of dry ice (200 g) was added gradually to a solution of dicyclohexylcarbodiimide (2.06 g, 0.01 mol), cyclohexylamine (1.98 g, 0.02 mol), and triethylamine (2.2 g, 0.02 mol) in THF at 75 ℃ over a period of 8 h. After stirring for 8 h, the reaction mixture was concentrated under reduced pressure and the resultant precipitate was collected. Fractional recrystallization of the precipitate from acetone/methanol gave N,N'-dicyclohexylurea; yield 2.2 g (98% based on dicyclohexylcarbodiimide and cyclohexylamine).
Synthesis Reference(s)
The Journal of Organic Chemistry, 61, p. 4175, 1996 DOI: 10.1021/jo9522825
N,N'-DICYCLOHEXYLUREA Preparation Products And Raw materials
Raw materials
Preparation Products
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