GS 39783 Chemical Properties

storage temp. 

Store at RT

solubility 

DMSO: ~8 mg/mL

form 

powder

color 

yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GS 39783 Usage And Synthesis

Uses

GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.

Definition

ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide.

Biological Activity

Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

storage

Store at RT

GS 39783(39069-52-8)Related Product Information

• GS 39783
• 4,5-DIAMINO-2-MERCAPTOPYRIMIDINE
• 4,6-Diamino-5-Nitro-2-Thiolpyrimidine
• 4,6-DIAMINO-5-NITROPYRIMIDINE
• 2-MERCAPTO-4,5,6-TRIAMINOPYRIMIDINE
• 4,6-DIAMINO-2-MERCAPTO-5-NITROSOPYRIMIDINE