2-Bromo-4-thiazolecarboxylic acid Chemical Properties

Melting point:

212-214

Boiling point:

350.0±15.0 °C(Predicted)

Density 

2.062±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.13±0.10(Predicted)

color 

White to Almost white

λmax

243nm(MeOH)(lit.)

InChI

InChI=1S/C4H2BrNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)

InChIKey

BEGREHRAUWCAHV-UHFFFAOYSA-N

SMILES

S1C=C(C(O)=O)N=C1Br

CAS DataBase Reference

5198-88-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29341000

Storage Class

11 - Combustible Solids

2-Bromo-4-thiazolecarboxylic acid Usage And Synthesis

Uses

Thiazole compounds are important pharmaceutical and chemical intermediates, characterized by low toxicity, excellent biological activities (such as acaricidal, bactericidal, and inhibitory effects on insect pheromone synthesis), and diverse structural variations. Thiazole 2-bromo-4-thiazolium carboxylic acid is a key intermediate in the synthesis of thiabendazole.

Chemical Properties

Pale yellow crystals

Synthesis

Ethyl 2-aminothiazole-4-carboxylate was synthesized solvent-free from thiourea and ethyl bromopyruvate as reagent, then ethyl 2-bromothiazole-4-carboxylate was obtained by high-temperature diazotization with DM SO and sodium nitrite, and finally the target 2-bromo-4-thiazolecarboxylate was obtained by saponification with potassium carbonate-methanol solution

2-Bromo-4-thiazolecarboxylic acid(5198-88-9)Related Product Information

• 2-Bromothiazole
• 2,2'-Dithiobis(benzothiazole)
• Benzothiazole
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Fosthiazate
• 2-Methyl-4-isothiazolin-3-one
• 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Methyl 2-bromothiazole-5-carboxylate
• 5-Thiazolecarboxylic acid, 2,4-dibromo-
• Ethyl 2-bromothiazole-4-carboxylate
• 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
• Ethyl 2-bromothiazole-5-carboxylate
• METHYL 2-BROMOTHIAZOLE-4-CARBOXYLATE
• ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• 2-BROMO-5-THIAZOLECARBOXYLIC ACID
• 4-Bromo-5-thiazolecarboxylic acid ethyl ester
• Bromine
• 2-Bromo-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid