Nicodicosapent Chemical Properties

Boiling point:

677.5±55.0 °C(Predicted)

Density 

1.013±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: ≥ 100 mg/mL (222.41 mM); Ethanol: 2 mg/mL (4.45 mM); Water: < 0.1 mg/mL (insoluble)

form 

Solid

pka

13.26±0.46(Predicted)

color 

Light yellow to yellow

Nicodicosapent Usage And Synthesis

Uses

Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

in vivo

References

[1] Vu CB, et al. Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid. J Med Chem. 2016 Feb 11;59(3):1217-31. DOI:10.1021/acs.jmedchem.5b01961