GLYX13
GLYX13 Basic information
- Product Name:
- GLYX13
- Synonyms:
-
- Rapastinel Trifluoroacetate
- GLYX 13,inhibit,Rapastinel Trifluoroacetate,GLYX13,GLYX-13,Inhibitor,Rapastinel,Ionotropic glutamate receptors,iGluR
- Rapastinel Trifluoroacetate, 10 mM in DMSO
- CAS:
- 1435786-04-1
- MF:
- C20H32F3N5O8
- MW:
- 527.5
- Mol File:
- 1435786-04-1.mol
GLYX13 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (236.97 mM)
- form
- Solid
- color
- White to off-white
GLYX13 Usage And Synthesis
Uses
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. Rapastinel Trifluoroacetate has the potential for major depressive disorder treatment.
in vivo
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P<0.01)[1]. Rapastinel Trifluoroacetate produces an antidepressant like effect in the USVs test, as indexed by an increase in hedonic 50-kHz USVs [F(1,20)=12.4, P<0.05] and a decrease in aversive 20-kHz USVs [F(1,20)=6.8, P<0.05]. Rapastinel Trifluoroacetate also produces an anxiolytic effect in the open field, as indexed by increased center time [F(1,20)=19.2, P<0.05] without altering locomotor activity as measured by line crosses [F(1,20)=0.0, P>0.05][2].
IC 50
NMDA Receptor
References
[1] Rajagopal L, et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behav Brain Res. 2016 Feb 15;299:105-10. DOI:10.1016/j.bbr.2015.10.060
[2] Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11. DOI:10.1016/j.neuroscience.2015.09.004
GLYX13Supplier
- Tel
- 1-516-6625404
- support@alfa-chemistry.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 021-31433387 15618786686
- sales@rechemscience.com
- Tel
- 0571-87213919
- Eric@peptidego.com
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com