GSK8814
GSK8814 Basic information
- Product Name:
- GSK8814
- Synonyms:
-
- GSK8814
- 1,7-Naphthyridin-2(1H)-one, 8-[[(3R,4R,5S)-3-[(4,4-difluorocyclohexyl)methoxy]-5-methoxy-4-piperidinyl]amino]-3-methyl-5-(5-methyl-3-pyridinyl)-
- GSK8814,GSK-8814
- CAS:
- 1997369-78-4
- MF:
- C28H35F2N5O3
- MW:
- 527.61
- Mol File:
- 1997369-78-4.mol
More
Less
GSK8814 Chemical Properties
- form
- Solid
- color
- Light yellow to yellow
More
Less
GSK8814 Usage And Synthesis
Biological Activity
GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].
References
[1]. Bamborough P, et al. A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. [2]. Bamborough P, et al. Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J Med Chem. 2018 Sep 27;61(18):8321-8336.
GSK8814Supplier
ChemCell Biomedicine Co.,Ltd.
- Tel
- 020-13556033878 2965585218 13556033878
- chemcell@hotmail.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
- Tel
- 86-571-88216897,88216896 13588875226
- sales@hzclap.com
ShangHai ChuanQian Chemcial Technique Centre
- Tel
- 15869524721
- 3525679403@qq.com