BocNH-PEG12-CH2CH2NH2
BocNH-PEG12-CH2CH2NH2 Basic information
- Product Name:
- BocNH-PEG12-CH2CH2NH2
- Synonyms:
-
- BocNH-PEG12-CH2CH2NH2
- 5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azatetracontanoic acid, 40-amino-, 1,1-dimethylethyl ester
- NHBoc-PEG12-amine
- Boc-N-amido-PEG12-amine
- inhibit,Inhibitor,PROTAC Linkers,Boc-NH-PEG-12-NH2,Boc NH PEG12 NH2,BocNHPEG12NH2
- BocNH-PEG12-CH2CH2NH2/5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azatetracontanoic acid, 40-amino-, 1,1-dimethylethyl ester
- tert-Butyl (38-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontyl)carbamate
- Boc-NH-PEG12-amine
- CAS:
- 1642551-09-4
- MF:
- C31H64N2O14
- MW:
- 688.84
- Mol File:
- 1642551-09-4.mol
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BocNH-PEG12-CH2CH2NH2 Chemical Properties
- Boiling point:
- 695.1±55.0 °C(Predicted)
- Density
- 1.088±0.06 g/cm3(Predicted)
- pka
- 12.23±0.46(Predicted)
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BocNH-PEG12-CH2CH2NH2 Usage And Synthesis
Biological Activity
Boc-NH-PEG12-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
BocNH-PEG12-CH2CH2NH2Supplier
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