ST034307 Chemical Properties

Boiling point:

329.1±42.0 °C(Predicted)

Density 

1.674±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)

form 

solid

color 

Yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

ST034307 Usage And Synthesis

Description

ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2

Uses

ST 034307 is a useful intermediate.

in vivo

storage

Store at -20°C

References

[1] TARSIS F. BRUST. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties[J]. Science Signaling, 2017, 10 467. DOI:10.1126/scisignal.aah5381
[2] ZHENG JIANG. Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.[J]. Journal of Chemical Theory and Computation, 2018: 652-664.e12. DOI:10.1016/j.cell.2018.08.055
[3] WATTS V J. Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain[J]. Neuropsychopharmacology, 2017, 43 1: 215-216. DOI:10.1038/npp.2017.190

ST034307(133406-29-8)Related Product Information

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