ST034307 Chemical Properties

Boiling point:

329.1±42.0 °C(Predicted)

Density 

1.674±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)

form 

solid

color 

Yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

ST034307 Usage And Synthesis

Description

ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2

Uses

ST 034307 is a useful intermediate.

storage

Store at -20°C

References

1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381 2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652 3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215

ST034307(133406-29-8)Related Product Information

• CILOSTAMIDE
• EPAC 5376753
• Vinpocetine
• RO 20-1724