Basic information Safety Supplier Related

RO 20-1724

Basic information Safety Supplier Related

RO 20-1724 Basic information

Product Name:
RO 20-1724
Synonyms:
  • 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE
  • 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE
  • 4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE
  • 4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE
  • 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE
  • ro 20-172
  • RO 20-1724
  • 4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
CAS:
29925-17-5
MF:
C15H22N2O3
MW:
278.35
Product Categories:
  • Cyclic Nucleotide related
  • A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase.
Mol File:
29925-17-5.mol
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RO 20-1724 Chemical Properties

Boiling point:
483.8±25.0 °C(Predicted)
Density 
1.099±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
ethanol: 7 mg/mL
form 
solid
pka
14.54±0.40(Predicted)
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
CAS DataBase Reference
29925-17-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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RO 20-1724 Usage And Synthesis

Description

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable

Uses

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.

Uses

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

Definition

ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.

Biological Activity

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

storage

Store at RT

References

1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19

RO 20-1724Supplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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VDM Biochemicals
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orderCN@merckgroup.com