RO 20-1724
RO 20-1724 Basic information
- Product Name:
- RO 20-1724
- Synonyms:
-
- 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE
- 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE
- 4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE
- 4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE
- 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE
- ro 20-172
- RO 20-1724
- 4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
- CAS:
- 29925-17-5
- MF:
- C15H22N2O3
- MW:
- 278.35
- Product Categories:
-
- Cyclic Nucleotide related
- A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase.
- Mol File:
- 29925-17-5.mol
RO 20-1724 Chemical Properties
- Boiling point:
- 483.8±25.0 °C(Predicted)
- Density
- 1.099±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- ethanol: 7 mg/mL
- form
- solid
- pka
- 14.54±0.40(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
- CAS DataBase Reference
- 29925-17-5(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
RO 20-1724 Usage And Synthesis
Description
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Uses
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Uses
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
Definition
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
storage
Store at RT
References
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19
RO 20-1724Supplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 0330-2528181
- sales@vdmbio.com
- Tel
- 021-60549325 18616193163
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
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- RO 20-1724
- 2-Imidazolidinone, 4-((3-(cyclopentyloxy)-4-methoxyphenyl)methyl)-
- AKOS BB-3072