Basic information Safety Supplier Related

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

Basic information Safety Supplier Related

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Basic information

Product Name:
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
Synonyms:
  • (4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
  • (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
  • (S)-(+)-ROLIPRAM
  • (R)-(-)-ROLIPRAM
  • (4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
  • Rolipram (R)-(-)-
  • (4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
  • (R)-(-)-Rolipram
CAS:
85416-75-7
MF:
C16H21NO3
MW:
275.34
Product Categories:
  • Signalling
  • Cyclic Nucleotide related
Mol File:
85416-75-7.mol
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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties

Melting point:
132.0 to 136.0 °C
Boiling point:
472.7±45.0 °C(Predicted)
Density 
1.155±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
White to off-white solid.
pka
16.02±0.40(Predicted)
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Safety Information

HazardClass 
IRRITANT
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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Usage And Synthesis

Uses

R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
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Sales-CN@TCIchemicals.com
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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Ascent Scientific
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4401179829988
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customerservice@ascentscientific.co.uk
Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005;021-58099637-8009
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bin.wu@shlschem.com;sales@shlschem.com