(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties

Melting point:

132.0 to 136.0 °C

Boiling point:

472.7±45.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

16.02±0.40(Predicted)

form 

White to off-white solid.

color 

Off-White

Safety Information

HS Code 

2933.79.8500

HazardClass 

IRRITANT

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Usage And Synthesis

Uses

R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Definition

ChEBI: (-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

storage

Room temperature

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE(85416-75-7)Related Product Information

• ZARDAVERINE
• RO 20-1724
• S- (+)-Rolipram
• 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
• ETAZOLATE
• BRL 50481
• Vinpocetine
• ZAPRINAST
• Cilostazol
• CILOSTAMIDE
• Pentoxifylline
• AG 1295
• 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
• EHNA HYDROCHLORIDE
• 4-(4'-Methoxyphenyl)-2-pyrrolidinone
• 4-(3'-Methoxyphenyl)-2-pyrrolidinone
• (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
• 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one