Mitiglinide calcium dihydrate Chemical Properties

Melting point:

179-185°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Methanol (Slightly)

form 

Solid

color 

White

InChIKey

QEVLNUAVAONTEW-HNIWBTCONA-L

SMILES

N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O |&1:2,8,14,29,42,48,r|

CAS DataBase Reference

207844-01-7(CAS DataBase Reference)

Mitiglinide calcium dihydrate Usage And Synthesis

Description

Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Chemical Properties

White Solid

Uses

KAD-1229 Calcium Hydrate (Mitiglinide calcium dihydrate) could binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.

Mechanism of action

Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia.

Mitiglinide calcium dihydrate(207844-01-7)Related Product Information

• Diethylstilbestrol
• Calcium oxide
• Benzyl alcohol
• Benzyl bromide
• Benzyl benzoate
• Calcium formate
• Calcium carbonate
• Calcium chloride
• Calcium Propionate
• [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid
• calcium sulfate
• Repaglinide
• cis-Octahydroisoindole
• CALCIUM ISOBUTYRATE
• Mivobulin
• MITIGLINIDE CALCIUM HYDRATE,Mitiglinide calcium,Mitiglinide calcium anhydrous
• CALCIUM
• Repaglinide Tablet